![]() The diagnosis of TGA should be made clinically. A complete version of this guideline (in German) can be found on the website of the Deutsche Gesellschaft für Neurologie ( and the AWMF (Arbeitsgemeinschaft wissenschaftlicher Medizinischer Fachgesellschaften). This guideline is a translated version of the german guideline “Transiente globale Amnesie”. Since the pathomechanism of TGA has not yet been definitively clarified, a multifactorial or multi-causal process seems likely, As empirical data are also lacking, no sufficiently evidence-based recommendations can be made regarding prophylaxis. In general, the prognosis of a TGA is very favorable. The diagnosis usually can be established in the acute stage based on the criteria of Caplan and Hodges and Warlow. The diagnosis of TGA is based on the patient’s history and that of others, as well as on clinical neurological and orienting neuropsychological examination, in particular the exclusion of possible differential diagnoses. Transient global amnesia (TGA) is characterized by a sudden onset of retrograde and anterograde amnesia for a period of one to a maximum of 24 h with an incidence between 3 and 8 per 100,000 population per year. There is no evidence for chronic sequelae of TGA with respect to cerebral ischemia, chronic memory impairment, or the onset of dementia-related syndromes. Because the pathomechanism of TGA is not yet clearly known, no evidence-based therapeutic or prophylactic recommendations can be made. ![]() Numerous findings in recent years point to a multifactorial genesis. ![]() TGA in patients < 50 years of age is a rarity, therefore it is mandatory to rapidly search for other causes in particular in younger patients. If additional DWI changes occur outside the hippocampus, a vascular etiology should be considered, and prompt sonographic and cardiac diagnostics should be performed EEG may help to differentiate TGA from rare amnestic epileptic attacks, especially in recurrent amnestic attacks. The sensitivity of MRI is considered higher when performed between 24 and 72 h after onset. The detection of typical unilateral or bilateral punctate DWI/T2 lesions in the hippocampus (especially the CA1 region) in a proportion of patients proves TGA. In case of an atypical clinical presentation or suspicion of a possible differential diagnosis, further diagnostics should be performed immediately. ![]() TGA is a disorder that occurs predominantly between 50 and 70 years. The incidence is estimated between 3 and 8 per 100,000 population/year. TGA is characterized by a sudden onset of retrograde and anterograde amnesia for a period of one to a maximum of 24 h (with an average of 6 to 8 h). ICD-10-CM G45.4 is grouped within Diagnostic Related Group(s) (MS-DRG v40.In 2022 the DGN (Deutsche Gesellschaft für Neurologie) published an updated Transient Global Amnesia (TGA) guideline. (from Adams et al., Principles of Neurology, 6th ed, pp429-30) Complete recovery normally occurs, and recurrences are unusual. The condition is related to bilateral dysfunction of the medial portions of each temporal lobe. During the period of amnesia, immediate and recent memory abilities are impaired, but the level of consciousness and ability to perform other intellectual tasks are preserved. It primarily occurs in middle aged or elderly individuals, and episodes may last from minutes to hours. A syndrome characterized by a transient loss of the ability to form new memories.Affected individuals lose memory function for recent events and have a decreased ability to retain new information. A condition characterized by sudden, temporary, usually short-lived memory loss, not associated with a neurologic disorder.Transient cerebral ischemic attacks and related syndromes transient retinal artery occlusion ( H34.0-).
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |